20 articles - From Friday Jun 17 2022 to Friday Jun 24 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Am J Clin Nutr |
Effects of a low FODMAP diet on the colonic microbiome in irritable bowel syndrome: a systematic review with meta-analysis. In patients with IBS, the effects of a low FODMAP diet on the colonic microbiome appear to be specific to Bifidobacteria with no consistent impacts on other microbiome metrics, including diversity, fecal SCFA concentrations and fecal pH. Further, adequately powered trials are needed to confirm these findings. CRD42020192243. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
A healthy plant-based diet is favorably associated with cardiometabolic risk factors among participants of South Asian ancestry. A higher intake of healthful plant-based foods was associated with a favorable cardiometabolic risk profile. Dietary recommendations to lower chronic disease risk among participants of South Asian ancestry should focus on the quality of plant-based foods. |
Associations between plasma tryptophan and indole-3-propionic acid levels and mortality in patients with coronary artery disease. Our findings suggest that plasma tryptophan and IPA levels are significantly associated with decreased risk of cardiovascular and all-cause mortality in CAD patients. Further studies are needed to determine the clinical diagnostic and therapeutic values of tryptophan and IPA levels on the risk of mortality among CAD patients. |
| Liver Transpl |
Low-dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation. Low-dose aspirin was associated with a lower risk of ACR and HAT after LT, especially in the first vulnerable year after transplantation. Therefore, low-dose aspirin use after primary LT should be evaluated to protect the liver graft from ACR and to maintain arterial patency. |
Multi-center study of racial & ethnic inequities in liver transplant evaluation: understanding mechanisms & identifying solutions. e., including but not limited to training of staff on health equity) to modifiable barriers in the clinical work system that could help patient navigation, reduce disparities, and improve access to care. Our findings call for an urgent need for transplant centers, national societies, and policy makers to focus efforts on improving equity (tailored, patient-centered resources) using the science of human factors and systems engineering. |
Outcome of Split Liver Transplantation from Pediatric Donors Weighing 25 kg or Less. Graft weight was the independent predictor of hepatic artery thrombosis (HAT). SLT using well-selected pediatric donors = |
Waitlist and Post-Transplantation Outcomes of Lean Individuals with Non-Alcoholic Fatty Liver Disease. NAFLD patients with normal weight have increased waitlist removal and those who remained at normal weight during the waitlisting period have worse post-transplant outcomes. Identifying and addressing factors influencing apparent healthy weight prior to LT is crucial to mitigate poor outcomes. |
| Pancreatology |
Clinical analysis of asparaginase-associated pancreatitis in children. According to the data from this single-center study, the incidence of AAP in patients with ALL was 3%, most of which occurred during the first or second exposure to asparaginase. Abdominal pain was the most common clinical manifestation. The diagnosis of AAP should be based on clinical manifestations, laboratory tests, and imaging findings. The prognosis of AAP is good, and whether asparaginase treatment can be reintroduced requires an evaluation of the benefits of asparaginase treatment and the risk of recurrence of pancreatitis. |
GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma. GPR120 promoted proliferation inhibition and apoptosis of PDAC, and contributed to PDAC metastasis via inducing EMT and angiogenesis. GPR120 served as a double-edged sword in the pathogenesis of PDAC. |
Morphological and functional recovery following acute and acute recurrent pancreatitis in children: A prospective sequential 2-point evaluation. More than one-quarter of children have evidence of altered glucose homeostasis and biochemical exocrine pancreatic insufficiency following an episode of AP. Similarly, morphological features of chronicity seen in some of the children suggest that a fraction of subjects may develop chronic pancreatitis on longer follow-up. |
Nal-IRI/5-FU/LV versus modified FOLFIRINOX and FOLFIRI as second-line chemotherapy for unresectable pancreatic cancer: A single center retrospective study. Given the trend toward longer OS in the mFFX group and the lower incidence of adverse events in the FOLFIRI group, both mFFX and FOLFIRI, as well as nal-IRI/5-FU/LV, can be treatment options for second-line chemotherapy for unresectable pancreatic cancer. |
Pain, depression, and poor quality of life in chronic pancreatitis: Relationship with altered brain metabolites. A significant proportion of patients with CP develops depression that correlate with poor QOL functions. Pain, depression, and emotional components of QOL in patients with CP correlated with N-acetyl aspartate and choline in the left hippocampus and left prefrontal cortex of the brain. |
Serum lipase on postoperative day one is a strong predictor of clinically relevant pancreatic fistula after pancreaticoduodenectomy: A retrospective cohort. Serum lipase on POD 1 outperformed serum amylase on POD 1 in predicting CR-POPF after PD. The combination of POD 1 serum lipase and POD 3 serum CRP provides a reliable predicting model for CR-POPF. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Liver Transpl |
| Pancreatology |
Circulating tumor DNA (ctDNA) to evaluate minimal residual disease (MRD), treatment response, and posttreatment prognosis in pancreatic adenocarcinoma. Detectable ctDNA after definitive resection, specifically mutated KRAS, correlates with shorter recurrence-free survival (RFS), overall survival (OS), and overall prognosis. Limited data also suggests ctDNA may provide a noninvasive means to assess response to chemotherapy. Whether this information is actionable in terms of altering neoadjuvant or postresection treatment regimens remains an open question requiring further study. |
Letters to the editors and authors’ replies
| Pancreatology |
all remaining publications eg case reports, images of the month, etc…
| Am J Clin Nutr |